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Following lessons learned coming out of the Spanish flu pandemic, Boots opened its first “Day & Night” store at Piccadilly Circus in London in 1925. John Boot stated that, “We decided that we ought to give a 24 hours’ service, seven days a week, so we finally selected Piccadilly Circus as being an address known to all, and convenient for bus and tube. Here we opened a purely chemist shop, where we have trained nurses as well as qualified chemists, and the number of customers during the nights and at weekends shows that it is much appreciated.”